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Invasive PNEUMOCOCCAL DISEASE

Invasive pneumococcal disease can put your child’s life at risk.

If invasive pneumococcal disease sounds scary, that’s because it is. It’s a group of illnesses caused by bacteria called pneumococcus bacteria. These airborne bacteria can easily enter your child’s body through the mouth or throat and invade parts of the body that are normally free from infection.

Here are two types of invasive pneumococcal disease and their risks:
  • Pneumococcal meningitis is a bacterial disease. It invades the tissues and fluids surrounding the brain and spinal cord. About 1 out of 10 children younger than 5 years old who get pneumococcal meningitis dies and others may have long-term problems, such as hearing loss or brain damage.
  • Bacteremia is a bacterial disease of the bloodstream that can cause a serious and potentially fatal infection. In fact, about 4 out of 100 infected children die from it.

It’s contagious. And babies are at greater risk.

Babies under 2 years old are at highest risk, and they can be infected almost anywhere they are. Pneumococcal bacteria are spread by close contact through sneezing, coughing, or even breathing. Some people can carry and spread invasive pneumococcal disease without being sick themselves. And if your little one is in day care, the risk of being infected may be more than twice as high.

Measles Mumps Hepatitis A Hib*
546 cases
Invasive Pneumococcal Disease
1,459cases
In 2011, children got invasive pneumococcal disease almost three times more often than four other serious diseases combined. This includes IPD caused by strains that are in the vaccine and those that are not in the vaccine.
* Includes invasive disease caused by Haemophilus influenzae nonserotype b and unknown serotype.
 Based on 2011 passive surveillance or notifiable disease cases among children <5 years of age reported to the Centers for Disease Control and Prevention (CDC). Policies for reporting notifiable disease cases can vary by disease or reporting jurisdiction.

How PREVNAR 13® helps protect against invasive pneumococcal disease.

The good news is that the PREVNAR 13® vaccine (called PCV13 on your baby’s immunization record) reduces the risk by helping protect against 13 of the most common strains of pneumococcal germs. Like all vaccines, it works with the body’s natural defenses to help develop immunity to disease. Learn more about how vaccines can help prevent disease from the Centers for Disease Control and Prevention (CDC).

Vaccines can help protect babies before they get sick.

Your body shielded your baby in the womb; vaccines help shield your baby by preventing disease. Antibiotics are only given after your baby is already ill. Because some pneumococcal germs have developed a resistance to certain antibiotics, these germs may be difficult to control. Prevention is a better approach.

PREVNAR 13<sup>®</sup> <br class='hidden-xs' />& Safety

Leading health organizations recommend PREVNAR 13® to help protect infants and young children, starting at 2 months of age and ending by 15 months, against invasive pneumococcal disease.

PREVNAR 13® is a vaccine given to babies, starting at age 2 months and ending at 15 months, to protect against 13 common strains of pneumococcal bacteria. It’s recommended by doctors at the American Academy of Pediatrics (AAP), and by the Centers for Disease Control and Prevention (CDC) and its Advisory Committee on Immunization Practices (ACIP) division.

“Vaccinating your child is as important as buckling them into their car seat.”
Dr. Denia Varrasso, MD
Fellow of the American Academy of Pediatrics

Look for PCV13 on your baby’s immunization record.

On your baby’s immunization record, PREVNAR 13® is called PCV13. And the AAP, CDC and ACIP recommend 4 doses of this vaccine, starting at 2 months and finishing by 15 months, to help protect your little one. You’ll find the recommended vaccine schedule here.

Most common side effects.

Having concerns about side effects is only natural. Here are the common ones that some children have experienced with PREVNAR 13®.

  • In children 6 weeks through 17 years, the most common side effects were tenderness, redness, or swelling at the injection site, irritability, decreased appetite, decreased or increased sleep, and fever.
  • The most commonly reported serious adverse events in infants and toddlers were bronchiolitis (inflammation of the lungs) (0.9%), gastroenteritis (inflammation of the stomach and small intestine) (0.9%), and pneumonia (0.9%).

Talk to your doctor about the potential risks and benefits of receiving the PREVNAR 13® vaccine.

Please see additional side effects and Important Safety Information.

VACCINE<br class='hidden-xs' /> SCHEDULE

4 doses of PREVNAR 13®, given on schedule, offer protection from invasive pneumococcal disease.

Your little one needs all 4 doses of PREVNAR 13® (called PCV13 on your baby’s immunization record). Getting that last dose is important because, after the 4th dose, the concentration of antibodies in your baby’s immune system is higher than it would be after just 3 doses. If your child receives less than 4 doses, his or her immune response may be lower during the time of greatest risk. To be sure that you and your doctor have done what you can to help protect your child against invasive pneumococcal disease, please keep all of your wellness appointments.

PREVNAR 13® (PCV13) schedulefor infants and toddlers.
Dosing§ based on when the vaccine will work best to boost your baby’s immune system.
2

months*†

4

months

6

months

12-15

months

*May be given as early as 6 weeks of age.
The recommended time between doses is 4-8 weeks apart.
The 4th dose should be given when your child is approximately12-15 months of age and at least 2 months after the 3rd dose.
§As recommended by the CDC Advisory Committee on ImmunizationPractices (ACIP) and the American Academy of Pediatrics (AAP).

What to ask your doctor.

Use the Doctor Discussion Guide to talk with your doctor about PREVNAR 13® and make sure your baby is protected.

Missed the schedule? It may not be too late.

While babies under 2 are at the highest risk, a high risk continues until age 5. If your child is 7 months through 5 years of age and hasn’t received PREVNAR 13® (PCV13 on your baby’s immunization record), use this catch-up schedule:

 

  • Children 7-11 months of age should receive 3 doses. The 1st 2 doses should be at least 4 weeks apart with the 3rd dose given after the 1-year birthday at least 2 months after the 2nd dose.
  • Children 12-23 months of age should receive 2 doses at least 2 months apart.
  • Children 24 months through 5 years of age (prior to the 6th birthday) should receive a single dose.

The immune responses induced by this catch-up schedule may result in less protection because of lower antibody concentrations for some serotypes compared to antibody concentrations following 4 doses of PREVNAR 13® (given at 2, 4, 6, and 12-15 months).

If your child is 6-17 years of age and has not previously received PREVNAR 13®, it is administered as a single dose.

Tips to help your little one feel more comfortable with their shots.

  • Distract and comfort your baby by cuddling, singing, or talking softly.
  • Smile and make eye contact to reassure your baby that everything’s OK.
  • Have your baby hold a favorite toy or blanket.
  • Ask if you can hold your baby on your lap, then gently rub his or her back during the vaccination.

COMMON<br class='hidden-xs' /> QUESTIONS

COMMON QUESTIONS

I’ve never heard of invasive pneumococcal disease. Should I be concerned?

Yes. Invasive pneumococcal diseases are still occurring in infants and young children in the United States. In March 2010, the CDC reinforced the need for vaccination against invasive pneumococcal diseases, based on recent reports of these diseases in children younger than 5 years of age.

How can I protect my baby against invasive pneumococcal disease?

While invasive pneumococcal diseases can be very serious in babies and young children, PREVNAR 13® (called PCV13 on your baby’s immunization schedule) can reduce this risk.

Is my child at a higher risk of invasive pneumococcal disease because he or she attends group day care?

Yes. Invasive pneumococcal disease spreads by physical contact and through the air by a cough or sneeze, and the risk of being infected is 2.5 times higher for children in group day care.

What is PREVNAR 13®?

PREVNAR 13® is a vaccine that is indicated for children 6 weeks through 5 years of age, and it helps protect against 13 of the most common strains of pneumococcal bacteria that cause invasive pneumococcal disease, such as pneumococcal meningitis. PREVNAR 13® is not 100% effective and will only help protect against the 13 strains in the vaccine.

Will my baby be fully protected even if I skip or delay a dose or two of PREVNAR 13®?

Your baby’s immune response to the vaccine may be lower if he or she receives fewer than all 4 doses. And if you delay a dose, your baby’s immune system may have a lower response during this time. PREVNAR 13® should be given as a complete 4-dose series at 2, 4, 6, and 12-15 months of age to help protect your baby against invasive pneumococcal diseases caused by the 13 strains in the vaccine during the period of greatest risk.